Utilizing explainable machine learning for progression-free survival prediction in high-grade serous ovarian cancer: insights from a prospective cohort study.

Background: High-grade serous ovarian cancer (HGSOC) remains one of the most challenging gynecological malignancies, with over 70% of ovarian cancer patients ultimately experiencing disease progression. The current prognostic tools for progression-free survival (PFS) in HGSOC patients have limitations. This study aims to develop an explainable machine learning (ML) model for predicting PFS in HGSOC patients.

Arechuines A-D, arecoline alkaloids from the peels of L.

Four novel arecoline alkaloid atropisomers, arechuines A-D (-), were obtained from the peels of L. Their structures were elucidated by UV, IR, MS and NMR spectra. The absolute configurations of (+)/(-)- were determined by comparing the experimental and calculated ECD spectra.

Mid-infrared absorption spectroscopy for and spatially resolved measurements of nitric oxide in premixed ammonia-methane co-fired flames.

Laser absorption spectroscopy (LAS) is a well-established measurement technique for quantitative chemical speciation in a combustion environment. However, LAS measurement of nitric oxide (NO) in ammonia flames has never been reported in the literature. This is despite the community's recent strong interest in carbon-neutral ammonia combustion and the associated NO formation problem.

Enantioselective reductive cross-couplings to forge C(sp)-C(sp) bonds by merging electrochemistry with nickel catalysis.

Motivated by the inherent benefits of synergistically combining electrochemical methodologies with nickel catalysis, we present here a Ni-catalyzed enantioselective electroreductive cross-coupling of benzyl chlorides with aryl halides, yielding chiral 1,1-diaryl compounds with good to excellent enantioselectivity. This catalytic reaction can not only be applied to aryl chlorides/bromides, which are challenging to access by other means, but also to benzyl chlorides containing silicon groups. Additionally, the absence of a sacrificial anode lays a foundation for scalability.