[Efficacy of conventional mono mac therapy and mono mac chronotherapy of painless myocardial ischemia in patients with insulin-independent diabetes].

60 patients, suffering from coronary heart disease with painless myocardial ischemia (PMI) and insulin-independent diabetes (IID), were randomized into two groups. The first group included 18 patients, who received conventional mono mac therapy in a dose of 20 mg twice a day, the second--42 patients, whose treatment consisted in mono mac chronotherapy, i.e.

[Radioprotective effect of acute hypoxia on 5-day-old mice preliminarily adapted to oxygen deficiency].

Studies of 5-day mice F1 (CBA X C57Bl) demonstrated that an exposure of animals to acute hypoxia (5% O2--95% N2) during their irradiation produced a different effect on the spleen and the growing cerebellar cortex. In these circumstances lesions of well oxygenated spleen tissues were noticeably reduced, whereas cerebellar cortex cells characterized by a low oxygen tension and a high tolerance to anoxia remained essentially unprotected. The findings are discussed in the light of adaptation concepts postulating that oxygen tension in cells is regulated, depending on the level of its uptake which in turn is determined by the relative oxygen content in the surrounding medium.