Publications by authors named "B Yucel"
Aim: This study investigates the impact of intracavitary pressure levels on pain, visualization quality, and procedure duration in office hysteroscopy, comparing standard pressures (60-100 mmHg) with high pressures (110-150 mmHg).
Methods: We conducted a retrospective cohort study involving non-menopausal women undergoing diagnostic hysteroscopy at a tertiary clinic. Patients were categorized into two groups based on intracavitary pressure: the standard pressure group (60-100 mmHg; n = 72) and the high-pressure group (110-150 mmHg; n = 37).
AMPK Activation in TET2 Downregulated Leukemia Cells Upon Glutamine Limitation.
Medeni Med J
September 2024
Article Synopsis
- - The study investigates how TET2 gene knockdown in acute myeloid leukemia (AML) cells affects their dependence on extracellular glutamine and their ability to survive in low-glutamine environments.
- - TET2-knockdown HL-60 cells showed decreased growth in glutamine-deficient conditions, yet they remained more viable than control cells, suggesting a potential adaptive mechanism.
- - Increased GLUL mRNA expression and P-AMPKα protein levels were observed in TET2-knockdown cells under low-glutamine conditions, indicating that these cells may have heightened reliance on glutamine for survival.
Here, we present an optimized acyl-PEGyl exchange gel shift (APEGS) assay to monitor palmitoylation of high-molecular-weight proteins from primary neuronal cultures. We describe steps for culturing cortical neurons from rat embryos and expressing proteins of interest. We then detail procedures for employing a fatty acyl exchange technique wherein hydroxylamine is used to cleave palmitic acid from the palmitoyl-thioester bond, exposing cysteine residues that are subsequently labeled with methoxy polyethylene glycol maleimide (mPEG-MAL-10k).
View Article and Find Full Text PDFAim: To evaluate survival and prognostic factors associated with survival among patients who underwent reirradiation for recurrent/ progressive primary brain tumors.
Material And Methods: A multicenter, retrospective study (7 centers, N=236) was conducted by the Neuro-oncology Group of the Turkish Radiation Oncology Association.
Results: Median overall survival (OS) was 11 months and 1- and 2-year survival rates were 48% and 22%, respectively.
Objectives: We aimed to develop a basic, easily applicable nomogram to improve the survival prediction of the patients with stage II/III gastric cancer (GC) and to select the best candidate for postoperative radiotherapy (RT).
Methods: In this multicentric trial, we retrospectively evaluated the data of 1597 patients with stage II/III GC after curative gastrectomy followed by postoperative RT ± chemotherapy (CT). Patients were divided into a training set (n = 1307) and an external validation set (n = 290).