Lithium Bond-Mediated Molecular Cascade Hydrogel for Injury-Free and Repositionable Adhesive Bioelectronic Interfaces.

Flexible bioelectronic interfaces with adhesive properties are essential for advancing modern medicine and human-machine interactions. However, achieving both stable adhesion and non-damaging detachment remains a significant challenge. In this study, a lithium bond-mediated molecular cascade hydrogel (LMCH) for bioelectronic interfaces is designed, which facilitates robust adhesion at the tissue level and permits atraumatic detachment for repositioning as required.

Hesperetin-Enhanced Metformin to Alleviate Cognitive Impairment via Gut-Brain Axis in Type 2 Diabetes Rats.

Diabetes constitutes a risk factor for cognitive impairment, whereas insulin resistance serves as the shared pathogenesis underlying both diabetes and cognitive decline. The use of metformin for treating cognitive impairment remains controversial. The present study found that hesperetin, a flavanone derived from citrus peel, enhanced metformin's efficacy in reducing blood sugar levels, improving insulin sensitivity, and ameliorating cognitive impairment in diabetic rats.

tailored confining microenvironment for lung cancer spheroids.

The mechanical properties and physical confinement of the extracellular matrix (ECM) are crucial roles in regulating tumor growth and progression. Extensive efforts have been dedicated to replicating the physical characteristics of tumor tissue by developing two-dimensional (2D) and three-dimensional (3D) models. However, it remains a significant challenge to modulate the local microenvironment around the specific cells according to the culture progress.

Emergence of a novel reassortant H3N3 avian influenza virus with enhanced pathogenicity and transmissibility in chickens in China.

H3N3 avian influenza viruses (AIVs) are less prevalent in poultry than H3N8 viruses. However, although relatively rare, reassortant H3N3 viruses have been known to appear in both domestic poultry and wild birds. In this study, we isolated the H3N3 virus in chickens sourced from a live poultry market in China.

Higher temperature sensitivity of forest soil methane oxidation in colder climates.

Forest soils, serving as an important sink for atmospheric methane (CH), modulate the global CH budget. However, the direction and magnitude of the forest soil CH sink under warming remain uncertain, partly because the temperature response of microbial CH oxidation varies substantially across geographical scales. Here, we reveal the spatial variation in the response of forest soil microbial CH oxidation to warming, along with the driving factors, across 84 sites spanning a broad latitudinal gradient in eastern China.