Integrated Mendelian Randomization and Single-Cell Transcriptomics Analysis Identifies Critical Blood Biomarkers and Potential Mechanisms in Epilepsy.

Background: Epilepsy has a genetic predisposition, yet causal factors and the dynamics of the immune environment in epilepsy are not fully understood.

Methods: We analyzed peripheral blood samples from epilepsy patients, identifying key genes associated with epilepsy risk through Mendelian randomization, using eQTLGen and genome-wide association studies. The peripheral immune environment's composition in epilepsy was explored using CIBERSORT.

Non-uniform failure mechanism and stability control of mining roadway under deviatoric stress field.

Based on the elastic-plastic theory, the analytical formula of the second invariant J of deviatoric stress at any point around the circular roadway under the non-uniform stress field is derived. The distribution law of J of surrounding rock under the three-dimensional non-isobaric stress field is studied by theoretical analysis and numerical simulation. Combined with the butterfly failure theory of surrounding rock of roadway, the close relationship between the distribution pattern of J and the distribution pattern of plastic zone is found, and the failure mechanism of surrounding rock is revealed.

Determining Rate Coefficients for the 11-Atom Reaction via Ring Polymer Molecular Dynamics Based on a 27-Dimensional Potential Energy Surface: The Reaction between -CHCHOO and HO.

Criegee intermediates (CIs) are potentially significant oxidants and a major source of OH radicals in the troposphere. The -CHCHOO intermediate has been confirmed as a crucial component of CIs in the atmospheric environment. Although previous studies have provided some experimental and theoretical rate constants, inconsistencies among these data remain, and the experimental data do not cover the full range of temperatures present in the troposphere.

Inhibition of Lymphangiogenesis: A Protective Role of microRNA 146a-5p in Breast Cancer.

Breast cancer is the leading cause of death and morbidity among women. A major challenge for clinical management of breast cancer is the dissemination of breast cancer cells from the primary tumor site via lymphatic drainage, resulting in metastatic tumor spread. Recent studies have found that high expression of the microRNA miR-146a-5p is associated with better survival outcomes for breast cancer patients.