Publications by authors named "B Wolfesberger"
Article Synopsis
- Feline eosinophilic sclerosing fibroplasia (FESF) is a rare inflammatory disease in cats that affects the gastrointestinal tract and can resemble tumors.
- A case series of 17 cats showed FESF linked with intralesional lymphoma, characterized by specific cell markers (CD56 and/or CD3) indicating a lymphocyte origin.
- This report introduces a new subtype of lymphoma associated with FESF, suggesting the term "eosinophilic sclerosing lymphoma."
Objectives: The standard treatment for canine and feline meningiomas includes radiotherapy, surgical excision or combined therapy. However, new therapeutic approaches are required due to the possible recurrence or progression of meningiomas despite initial therapy. Adjunctive therapy with synthetic long-acting somatostatin (SST) analogues has been described in humans with SST-expressing tumours.
View Article and Find Full Text PDFLymphoma is the most common tumour of domestic cats, developing most frequently in the small intestine. Feline small intestinal lymphoma predominantly demonstrates a T-cell immunophenotype identified by standard immunopositivity for T cells with CD3 or immunopositivity for B cells with CD20. In contrast, a wide spectrum of immunohistochemical antibodies are applied in humans to diagnose the various specific lymphoma subtypes according to the WHO classification.
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- - Gastrointestinal lymphoma is the most prevalent lymphoma in cats, with aggressive forms being rare and having a poor prognosis; due to sampling challenges, immunophenotyping isn't typically performed.
- - A study involving 32 cats diagnosed and categorized their gastrointestinal lymphomas using flow cytometry immunophenotyping, linking it to the WHO classification and clonality testing.
- - The study found high agreement between histopathology and flow cytometry, with 87.5% of cases showing consistency and positive clonality results in 87.5% of the patients, marking a significant advancement in lymphoma subtype identification.
Gastrointestinal lymphomas are uncommon in dogs and little is known about their distinct subtypes or proliferation rate. The aim of this study was to stratify 33 canine gastrointestinal lymphoma samples according to the latest World Health Organization classification and to determine the Ki67 proliferation index by manual counting, digital image analysis and visual estimation. The Ki67 index was then correlated with subtype, immunophenotype, mitotic index, grade and tumour location.
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