Publications by authors named "B Wiggs"

Article Synopsis
  • Whole-exome sequencing has enhanced the diagnosis of genetic diseases, leading to the development of a clinical metabolomics method that uses mass spectrometry to screen for metabolic disorders by measuring hundreds of metabolites in a single sample.
  • A precision study was conducted on human plasma to assess the reliability of four high-throughput metabolomics platforms, revealing a range of laboratory and inter-assay coefficient of variations (CVs) indicating good precision across samples.
  • The evaluation confirms that the method is robust and reproducible for identifying key metabolites related to inborn errors of metabolism (IEMs), demonstrating its effectiveness in patient screening through consistent analytical results.
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A two-layer model is used to simulate the mechanical behavior of an airway or other biological vessel under external compressive stress or smooth muscle constriction sufficient to cause longitudinal mucosal buckling. Analytic andfinite element numerical methods are used to examine the onset of buckling. Post-buckling solutions are obtained by finite element analysis, then verified with large-scale physical model experiments.

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Alterations in airway wall anatomic properties and the consequential effects on airway narrowing have been assessed by use of computational models. In these models, it is generally assumed that at zero transmural pressure the airway wall exists in a zero-stress state. Many studies have shown that this is often not the case, as evidenced by a nonzero opening angle.

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The University of Calgary's Faculty of Medicine and the Calgary Regional Health Authority understand that telehealth is an evolving field requiring both academic enquiry and operational readiness. Both parties are committed to quality educational programmes--the Faculty through its commitment to excellence and the Authority with its charge to maintain and enhance such programmes. There are shared applications, multi-learner user groups, shared strategies to overcome distances and shared infrastructure--technologies, communication pathways and resources.

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