Publications by authors named "B Wielockx"
Embryonic neurogenesis can be defined as a period of prenatal development during which divisions of neural stem and progenitor cells give rise to neurons. In the central nervous system of most mammals, including humans, the majority of neocortical neurogenesis occurs before birth. It is a highly spatiotemporally organized process whose perturbations lead to cortical malformations and dysfunctions underlying neurological and psychiatric pathologies, and in which oxygen availability plays a critical role.
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- A specific group of dormant hematopoietic stem cells (dHSCs) acts as a reserve pool to protect against exhaustion, but too much dormancy can hinder responses to blood system stress.
- Researchers discovered that CD38 serves as a key marker for identifying dHSCs and found that the cADPR signaling pathway, regulated by CD38, plays a crucial role in maintaining dHSC dormancy by influencing a protective cell cycle inhibitor.
- Understanding this CD38/cADPR/Ca2+/c-Fos/p57Kip2 pathway could lead to new methods to enhance stem cell transplant effectiveness and promote blood recovery post-injury or illness.
Oxygen sensing is of paramount importance for maintaining cellular and systemic homeostasis. In response to diminished oxygen levels, the hypoxia-inducible factors (HIFs) orchestrate various biological processes. These pivotal transcription factors have been identified as key regulators of several biological events.
View Article and Find Full Text PDFCurrent therapies for metastatic osseous disease frequently fail to provide a durable treatment response. To date, there are only limited therapeutic options for metastatic prostate cancer, the mechanisms that drive the survival of metastasis-initiating cells are poorly characterized, and reliable prognostic markers are missing. A high aldehyde dehydrogenase (ALDH) activity has been long considered a marker of cancer stem cells (CSC).
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