Publications by authors named "B Wertheim"
A bottleneck in sustainable fruit production is the replacement of chemical products with natural compounds. Matrine and oxymatrine, derived from a Chinese medicinal herb, have exhibited potential for controlling agricultural pests. However, there is no information regarding their effectiveness in managing dipterans.
View Article and Find Full Text PDFHypoxia-inducible factor 1α (HIF1α) is a master regulator of biological processes in hypoxia. Yet, the mechanisms and biological consequences of aerobic HIF1α activation by intrinsic factors, particularly in normal (primary) cells, remain elusive. Here we show that HIF1α signalling is activated in several human primary vascular cells in normoxia and in vascular smooth muscle cells of normal human lungs.
View Article and Find Full Text PDFEndothelial dysfunction is an underlying mechanism for the development of pulmonary arterial hypertension (PAH). Vascular endothelial growth factor (VEGF) and stromal cell-derived factor-1α (SDF) may help repair the dysfunctional endothelium and provide treatment for PAH. To examine this possibility, nanoparticles carrying human recombinant VEGF and SDF (VEGFNP and SDFNP) were aerosolized into the lungs of nude rats at Day 14 after monocrotaline (MCT) injection and analyses were performed at Day 28.
View Article and Find Full Text PDFArticle Synopsis
- The study focused on how diet affects the gut microbiota and development of houseflies (Musca domestica) reared on different substrates: control (wheat bran), high-fat (clotted cream), and high-sugar (sucrose).
- A high-sugar diet resulted in lower developmental success and less diverse gut microbiota, leading to a shift in dominant bacteria, particularly a rise in Weissella and a decline in lactobacilli.
- Introducing beneficial bacteria strains isolated from control larvae helped mitigate the negative effects of the high-sugar diet, showing that microbiome manipulation can improve growth and restore bacterial diversity.