Publications by authors named "B Watts"
Antibody-drug conjugates (ADCs) combining monoclonal antibodies with cytotoxic payloads are a rapidly emerging class of immune-based therapeutics with the potential to improve the treatment of cancer, including children with relapse/refractory acute lymphoblastic leukemia (ALL). CD123, the α subunit of the interleukin-3 receptor, is overexpressed in ALL and is a potential therapeutic target. Here, we show that pivekimab sunirine (PVEK), a recently developed ADC comprising the CD123-targeting antibody, G4723A, and the cytotoxic payload, DGN549, was highly effective in vivo against a large panel of pediatric ALL patient-derived xenograft (PDX) models ( = 39).
View Article and Find Full Text PDFObjective: Mental health care is delivered by teams that include social workers, psychologists, nonphysician prescribing clinicians (NPPCs), and physicians. The objective of this study was to determine whether patient rurality has an effect on the types of U.S.
View Article and Find Full Text PDFArticle Synopsis
- - The research focuses on developing small-molecule inhibitors (SMIs) targeting the CD40-CD40L interaction to improve islet transplantation outcomes and prevent type 1 diabetes (T1D) in mice.
- - Promising SMIs DRI-C21041 and DRI-C21095 demonstrated the ability to prolong islet allograft survival and functionality while reducing T1D incidence in NOD mice during trials.
- - These findings suggest that CD40L-targeting SMIs could provide a safer and more effective alternative to traditional antibody treatments, offering better control and ease of administration for transplant recipients and autoimmune disease prevention.
Objective: The aim of the study is to characterize geographic variation in electroconvulsive therapy (ECT) receipt across the United States (US) Veterans Administration (VA) healthcare system and explore potential explanatory variables.
Background: ECT is a highly effective and rapidly acting treatment for multiple mental disorders. However, there may be geographic disparities in access to ECT across the US.