Publications by authors named "B Waschki"
Chronic obstructive pulmonary disease (COPD) is commonly associated with ageing, with the prevalence and severity increasing by age. Smoking-induced premature ageing is thought to contribute to COPD, particularly lung emphysema. This study aimed to explore the relationship between lung function impairment and skin texture, as a marker of biological or premature ageing, in COPD patients.
View Article and Find Full Text PDFBackground: Patients with COPD are often affected by loss of bone mineral density (BMD) and osteoporotic fractures. Natriuretic peptides (NP) are known as cardiac markers, but have also been linked to fragility-associated fractures in the elderly. As their functions include regulation of fluid and mineral balance, they also might affect bone metabolism, particularly in systemic disorders such as COPD.
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- In patients with COPD, impaired left ventricular (LV) filling can be categorized into two patterns: small LV size and heart failure with preserved ejection fraction (HFpEF), both linked to increased all-cause mortality.
- A study involving 1,752 COPD patients found that 8% had small LV, 16% had HFpEF features, and 45% had normal cardiac function, with those having small LV or HFpEF showing significantly higher mortality rates.
- Small LV is an independent predictor of mortality, contrasting with HFpEF as patients with small LV exhibit reduced LV filling but normal filling pressure and lower biomarker levels.
Background: The evidence regarding effects of statins on exacerbation risk in COPD remains controversial. Previous studies often excluded patients with cardiovascular comorbidities despite their high prevalence in COPD and role for exacerbations. Based on the cardioprotective properties of statins, we hypothesised that statins may reduce the risk of exacerbations especially in patients with cardiovascular comorbidities.
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