Publications by authors named "B Ware"
Ross River virus (RRV) and other alphaviruses cause chronic musculoskeletal syndromes that are associated with viral persistence, which suggests deficits in immune clearance mechanisms, including CD8 T-cell responses. Here, we used a recombinant RRV-gp33 that expresses the immunodominant CD8 T-cell epitope of lymphocytic choriomeningitis virus (LCMV) to directly compare responses with a virus, LCMV, that strongly induces antiviral CD8 T cells. After footpad injection, we detected fewer gp33-specific CD8 T cells in the draining lymph node (DLN) after RRV-gp33 than LCMV infection, despite similar viral RNA levels in the foot.
View Article and Find Full Text PDFLead isotopes are a powerful geochemical tracer and a popular tool applied across a broad range of scientific fields, e.g., earth sciences, archaeology, and forensic sciences.
View Article and Find Full Text PDFInfection by chikungunya virus (CHIKV), a mosquito-borne alphavirus, causes severe polyarthralgia and polymyalgia, which can last in some people for months to years. Chronic CHIKV disease signs and symptoms are associated with the persistence of viral nucleic acid and antigen in tissues. Like humans and nonhuman primates, CHIKV infection in mice results in the development of robust adaptive antiviral immune responses.
View Article and Find Full Text PDFArticle Synopsis
- - Alphaviruses, transmitted by mosquitoes, cause high levels of the virus in the bloodstream that help in spreading the infection to new hosts through a two-phase transport mechanism to the draining lymph node (DLN).
- - The first phase of transport occurs shortly after infection before the virus replicates, while the second phase requires the virus to replicate in the skin, enabling it to enter the bloodstream.
- - Depleting a specific type of immune cell called Ly6C monocytes reduces infection rates in the skin, slows down the transport of the virus to the DLN, and delays its spread to other body parts, indicating that these monocytes play a crucial role in enhancing alphavirus infection and spread.
Infection by chikungunya virus (CHIKV), a mosquito-borne alphavirus, causes severe polyarthralgia and polymyalgia, which can last in some people for months to years. Chronic CHIKV disease signs and symptoms are associated with the persistence of viral nucleic acid and antigen in tissues. Like humans and nonhuman primates, CHIKV infection in mice results in the development of robust adaptive antiviral immune responses.
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