[The effect of fenoterol (partusisten) on cAMP and cGMP concentrations, acetylcholine esterase and choline acetyltransferase activities in rat placenta].

Several observations indicate a possible role of the placental cholinergic system in the modulation and maintenance of placental function and subsequently fetal growth and development. We have investigated the effect of Partusisten (1 mg/kg p.o.

[Pharmacokinetics of 6-mercaptopurine in rats during postnatal development].

It was shown that 6-MP pharmacokinetics in rats was age-dependent. The distribution processes were mainly influenced by age of animals. 6-MP total distribution volume (VD) increased from 26.

[Chloramphenicol metabolism in the tissues of newborn and adult rabbits].

The in vitro studies on the metabolism of chloramphenicol in the liver, kidney and lung of 5 days old and adult rabbit as well as in the placenta (20-23 day of gestation) have been performed. The metabolites have been identified by thin-layer chromatography technique. Nonmetabolized chloramphenicol and reduction product were estimated by spectrophotometric method.

[Serotonin concentration in the rat fetal brain in experimental intrauterine dystrophy].

The concentration of serotonin (5-hydroxytryptamine, 5-HT) was determined in the brain of fetal rats with experimental intrauterine growth retardation (IUGR). IUGR was induced using the procedure of Wigglesworth. On the 17th day of gestation, the uterine artery supplying one uterine horn was ligated.