Publications by authors named "B Walzog"
S100A8/A9 is an endogenous alarmin secreted by myeloid cells during many acute and chronic inflammatory disorders. Despite increasing evidence of the proinflammatory effects of extracellular S100A8/A9, little is known about its intracellular function. Here, we show that cytosolic S100A8/A9 is indispensable for neutrophil post-arrest modifications during outside-in signaling under flow conditions in vitro and neutrophil recruitment in vivo, independent of its extracellular functions.
View Article and Find Full Text PDFArticle Synopsis
- Helicobacter pylori (H. pylori) is a type of bacteria that can live in the human stomach and make people sick by causing infections.
- This bacteria has clever ways to hide from the body's immune system, such as changing its surface to avoid detection and blocking important signals that help fight infections.
- Scientists used a special imaging technique on mice to see how immune cells, like neutrophils and macrophages, react to H. pylori in real-time, which helps them understand how infections work better.
Article Synopsis
- Platelet homeostasis is vital for blood vessel stability and immune response, but the mechanisms behind the replenishment of their precursor cells (megakaryocytes) are not well understood.
- Researchers used intravital imaging to discover that plasmacytoid dendritic cells (pDCs) act as sensors in the bone marrow that detect dying megakaryocytes and stimulate the proliferation of their progenitor cells through the release of IFNα.
- The study highlights that while pDCs usually help fight viral infections, their activation by viruses like SARS-CoV-2 disrupts their monitoring function, leading to an overproduction of megakaryocytes.
Newborns are at high risk of developing neonatal sepsis, particularly if born prematurely. This has been linked to divergent requirements the immune system has to fulfill during intrauterine compared with extrauterine life. By transcriptomic analysis of fetal and adult neutrophils, we shed new light on the molecular mechanisms of neutrophil maturation and functional adaption during fetal ontogeny.
View Article and Find Full Text PDFArticle Synopsis
- * Researchers analyze neutrophils from patients with known genetic variations, identifying key differences in their protein composition (proteome).
- * Experiments using human stem cells and zebrafish models show that SRP deficiency disrupts important cellular processes needed for proper neutrophil development.