[Manifestation of glutathione S-transferase GSTM1 and GSTT1 in female patients with bleomycin-positive chromosome instability].

Objectives: The purpose of this research is to assess the incidence of gene polymorphisms coding the GSTM1 and GSTT1 enzymes in a population of female patients with chromosome instability.

Materials And Methods: The PCR method was used to determine the genotype for GSTM1 and GSTT1. The breaks per cell and the percentage of damaged cells were calculated.

[Analysis of clinical usefulness of the cytologic smear results for pregnant women using the Bethesda system].

The aim of this paper was to analyse the clinical usefulness of cytological smear results for pregnant women by use of Bethesda system. The examinations were carried for 5 years and correct results of cytological assays were achieved from 3265 patients. Low and high grade squamous intraepithelial cells were reported in 4.

Function of insulin-like growth factor (IGF-I) and its binding protein (IGFBP-1) in pathological proliferation of endometrium.

The purpose of this project was the investigation of insulin, IGF-I and IGFBP-1 concentrations in the serum of patients with pathological changes in endometrium. IGF-I and its binding protein (IGFBP-1) stimulate cell growth and differentiation of the normal and neoplastic endometrium. The mean values of IGF-I concentrations in the group of patients with atypical hyperplasia and endometrial carcinoma were significantly higher than in the control group with normal endometrium.

[Detection of human papillomavirus genome in cervical squamous intraepithelial lesions].

Objectives: The aim of this work was the assessment of the correlation between different types of HPV and abnormal stages of uterine cervix.

Materials And Methods: The smears were simultaneously collected for both cytooncologic examination and PCR identification of HPV viruses. Cytologic smears were classified according to the Bethesda system.

[Chromosome instability in women with genital organs carcinoma].

Objectives: The aim of the current work was the assessment of the mutagen susceptibility of chromosomes of patients with carcinomas in comparison to healthy volunteers. It was interesting whether the bleomycin assay can be useful for searching for more susceptible to cancer disease individuals.

Materials And Methods: There were 4 groups of patients analysed: controls and three test groups (patients with uterine cervix carcinoma, endometrium carcinoma and ovarian carcinoma).