Publications by authors named "B W Scheuermann"
Article Synopsis
- The PREVENT equations were developed by the American Heart Association to improve the assessment of cardiovascular disease (CVD) risk, aiming to facilitate treatment initiation and enhance communication between patients and clinicians.* -
- The study utilized National Health and Nutrition Examination Survey (NHANES) data from 1999 to 2010, focusing on a diverse US adult population with a 10-year follow-up to evaluate the effectiveness of these equations in predicting CVD-related mortality.* -
- Results showed that the PREVENT equations had a strong ability to predict CVD risk, with a significant association between higher risk estimates and increased mortality, achieving a high discrimination score, although exhibiting some moderate underfitting in the model.*
Background: 5-fluorouracil (5-FU) is the second most common cancer chemotherapy associated with short- and long-term cardiotoxicity. Although the mechanisms mediating these toxicities are not well understood, patients often present with symptoms suggestive of microvascular dysfunction. We tested the hypotheses that patients undergoing cancer treatment with 5-FU based chemotherapy regimens would present with impaired microvascular reactivity and that these findings would be substantiated by decrements in endothelial nitric oxide synthase (eNOS) gene expression in 5-FU treated human coronary artery endothelial cells (HCAEC).
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- Cerebral small vessel disease (cSVD) is linked to ischemic stroke and dementia, and this systematic review aims to clarify its relationship with cerebrovascular reactivity (CVR), cerebral autoregulation, and arterial stiffness (AS).
- The review analyzed 142 studies and conducted meta-analyses on 60 of them, revealing that CVR, cerebral autoregulation, and AS were significantly associated with cSVD in a majority of cases.
- The findings indicate a borderline association between impaired CVR and cSVD, and a strong link between increased AS and cSVD, suggesting that further research into these vascular factors as potential risk contributors is necessary.
In non-cancer populations, inorganic dietary nitrate (NO) supplementation is associated with enhanced cardiorespiratory function but remains untested in patients with a history of cancer. Therefore, this pilot study sought to determine if oral NO supplementation, as a supportive care strategy, increases left ventricular (LV) function and exercise performance in survivors of cancer treated with anticancer therapy while simultaneously evaluating the feasibility of the methods and procedures required for future large-scale randomized trials. Two cohorts of patients with a history of cancer treated with anticancer chemotherapy were recruited.
View Article and Find Full Text PDFToday's scientific data analysis very often requires complex Data Analysis Workflows (DAWs) executed over distributed computational infrastructures, e.g., clusters.
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