Publications by authors named "B W Kuvshinoff"
Importance: Changes in postsurgical opioid prescribing practices may help reduce chronic opioid use in surgical patients.
Objective: To investigate whether postsurgical acute pain across different surgical subspecialties can be managed effectively after hospital discharge with an opioid supply of 3 or fewer days and whether this reduction in prescribed opioids is associated with reduced new, persistent opioid use.
Design, Setting, And Participants: In this prospective cohort study with a case-control design, a restrictive opioid prescription protocol (ROPP) specifying an opioid supply of 3 or fewer days after discharge from surgery along with standardized patient education was implemented across all surgical services at a tertiary-care comprehensive cancer center.
Article Synopsis
- - The NCCN Guidelines for Neuroendocrine and Adrenal Gland Tumors provide a framework for the diagnosis, treatment, and management of various tumors such as neuroendocrine tumors (NETs), adrenal tumors, pheochromocytomas, and paragangliomas.
- - These guidelines stress the importance of a multidisciplinary approach, involving various specialists like pathologists, endocrinologists, and oncologists, to accurately diagnose and treat these tumors.
- - The 2021 update of the guidelines includes recommendations on genetic risk assessment, counseling, and management strategies for specific types of tumors, including well-differentiated grade 3 NETs and neuroendocrine carcinomas.
Background: Immunotherapeutic approaches for pancreatic ductal adenocarcinoma (PDAC) are less successful as compared to many other tumor types. In this study, comprehensive immune profiling was performed in order to identify novel, potentially actionable targets for immunotherapy.
Methods: Formalin-fixed paraffin embedded (FFPE) specimens from 68 patients were evaluated for expression of 395 immune-related markers (RNA-seq), mutational burden by complete exon sequencing of 409 genes, PD-L1 expression by immunohistochemistry (IHC), pattern of tumor infiltrating lymphocytes (TILs) infiltration by CD8 IHC, and PD-L1/L2 copy number by fluorescent in situ hybridization (FISH).
Article Synopsis
- A randomized trial suggested that pasireotide could reduce postoperative pancreatic fistula (POPF) rates, but other studies failed to support this finding.
- In this study, patients who underwent pancreatoduodenectomy or distal pancreatectomy were analyzed, comparing those treated with pasireotide to a retrospective control group.
- Results showed no significant difference in rates of clinically relevant POPF between the pasireotide group and control, indicating that pasireotide did not effectively lower the risk of CR-POPF.
Background: Regulatory approval of next generation sequencing (NGS) by the FDA is advancing the use of genomic-based precision medicine for the therapeutic management of cancer as standard care. Recent FDA guidance for the classification of genomic variants based on clinical evidence to aid clinicians in understanding the actionability of identified variants provided by comprehensive NGS panels has also been set forth. In this retrospective analysis, we interpreted and applied the FDA variant classification guidance to comprehensive NGS testing performed for advanced cancer patients and assessed oncologist agreement with NGS test treatment recommendations.
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