Effect of apolipoprotein A-IV genotype and dietary fat on cholesterol absorption in humans.

We investigated the effect of the A-IV-2 allele, which encodes a Q360H substitution in apolipoprotein (apo) A-IV, and dietary fat on cholesterol absorption in humans. In three separate studies we compared fractional intestinal cholesterol absorption between groups of subjects heterozygous for the A-IV-2 allele (1/2) and homozygous for the common allele (1/1) receiving high cholesterol ( approximately 800 mg/day) diets with different fatty acid compositions. All subjects had the apoE 3/3 genotype.

Reversible esophageal motility disorder in a patient with sarcoidosis.

We report the case of a patient who presented with new onset of dysphagia for solids and liquids. Her condition was subsequently diagnosed as sarcoidosis on the basis of granulomatous inflammation in tissue obtained from transbronchial fine needle aspiration, noncaseating granulomas in a full-thickness lip biopsy, mild uveitis on slit lamp examination, and serum angiotensin-converting enzyme activity of 120 U/L. Esophageal manometry revealed a nonspecific esophageal motility disorder with 60% nontransmitted contractions and a lower esophageal sphincter that failed to relax with wet swallows.

Renal hypertrophy in streptozotocin diabetic rats: role of proteolytic lysosomal enzymes.

Renal protein mass increases in diabetic renal hypertrophy. Accretion of protein may be the result of increased protein synthesis and/or decreased protein degradation. The lysosomal proteases, cathepsins B and L, are key enzymes in cellular protein catabolism.