Publications by authors named "B W Ellis"
Guided by concepts from life history (LH) theory, a large human research literature has tested the hypothesis that exposures to extrinsic mortality (EM) promote the development of faster LH strategies (e.g., earlier/faster reproduction, higher offspring number).
View Article and Find Full Text PDFRemote monitoring of rheumatoid arthritis (REMORA): study protocol for a stepped wedge cluster randomized trial and process evaluation of an integrated symptom tracking intervention.
Trials
October 2024
Background: Management of rheumatoid arthritis (RA) relies on symptoms reported by patients during infrequent outpatient clinic visits. These reports are often incomplete and inaccurate due to poor recall, leading to suboptimal treatment decisions and outcomes. Asking people to track symptoms in-between visits and integrating the data into clinical pathways may improve this.
View Article and Find Full Text PDFArticle Synopsis
- This research focuses on the aggregation of dipeptide-repeat (DPR) proteins linked to familial amyotrophic lateral sclerosis/frontotemporal dementia (ALS/FTD), which are often not efficiently modeled in cell cultures.* -
- Using optogenetics, the study achieved controlled aggregation of poly-PR proteins in human motor neurons, revealing unique nuclear condensates that resemble TDP-43 anisosomes and indicating that RNA limits their growth.* -
- The findings suggest that poly-PR condensation and abnormal TDP-43 interaction may represent an early pathological event in ALS/FTD, potentially linking this process to broader neurodegenerative disease mechanisms.*
Highlight selection of radiochemistry and radiopharmacy developments by editorial board.
EJNMMI Radiopharm Chem
September 2024
Background: The Editorial Board of EJNMMI Radiopharmacy and Chemistry releases a biannual highlight commentary to update the readership on trends in the field of radiopharmaceutical development.
Main Body: This selection of highlights provides commentary on 19 different topics selected by each coauthoring Editorial Board member addressing a variety of aspects ranging from novel radiochemistry to first-in-human application of novel radiopharmaceuticals.
Conclusion: Trends in radiochemistry and radiopharmacy are highlighted.