Publications by authors named "B W Dubois"
Breast Cancer Specificities of Patients With Anti-Ri Paraneoplastic Neurologic Syndromes.
Neurol Neuroimmunol Neuroinflamm
March 2025
Background And Objectives: Breast cancers (BCs) of patients with paraneoplastic neurologic syndromes and anti-Yo antibodies (Yo-PNS) overexpress human epidermal growth factor receptor 2 (HER2) and display genetic alterations and overexpression of the Yo-onconeural antigens. They are infiltrated by an unusual proportion of B cells. We investigated whether these features were also observed in patients with PNS and anti-Ri antibodies (Ri-PNS).
View Article and Find Full Text PDFDendritic cells (DCs) are promising targets for cancer immunotherapies because of their central role in the initiation and control of immune responses. The rare cDC1 population is of particular interest because of its remarkable ability to cross-present antigens (Ag) to CD8+ T cells, to promote Th1 cell polarization and NK cell activation and recruitment. However, the spatial organization and specific functions of cDC1s in response to immunotherapy remain to be clearly characterized in human tumors.
View Article and Find Full Text PDFArticle Synopsis
- The study of taxonomic composition has shifted from traditional methods to advanced DNA sequencing techniques, particularly metabarcoding, which uses targeted genome portions for high-throughput sequencing.
- Recent innovations in Oxford Nanopore Technologies have made sequencing more accessible and effective while presenting specific errors and a need for refined bioinformatics tools to handle long-read data.
- PRONAME, a new open-source pipeline designed for Nanopore data, enhances sequence accuracy and supports custom database integration, achieving over 99.5% accuracy in tests, thus providing a reliable method for analyzing complex biological communities.
Episodic memory (EM) alterations are a hallmark of Alzheimer's disease (AD). We assessed EM longitudinally in cognitively normal elders at-risk for AD (with subjective memory complaints), as a function of amyloid-β (Aβ) burden, neurodegeneration (N), and progression to prodromal AD. We stratified 264 INSIGHT-preAD study subjects in controls (Aβ-/N-), stable/N- or N + (Aβ +), and progressors/N- or N + (Aβ +) groups (progressors were included only until AD-diagnosis).
View Article and Find Full Text PDFBackground: Blood pressure (BP) control in haemodialysis (HD) patients is essential. Peri-dialytic BP levels do not accurately diagnose hypertension or predict the cardiovascular (CV) mortality.
Methods: In this study, we recruited 43 adult patients who had been on chronic HD for ≥3 months.