Publications by authors named "B W Benson"
Article Synopsis
- T follicular helper (Tfh) cells, which are important for antibody production, rely heavily on the immunoreceptor PD-1, and its deficiency leads to weakened Tfh functions and impaired immune responses in mice.
- Individuals lacking PD-1 or PD-L1 demonstrate fewer memory B cells and diminished antibody responses, highlighting the critical role of these molecules in immune system functionality.
- PD-1 influences both the intrinsic and extrinsic aspects of B cell memory and antibody production, suggesting that disruptions in PD-1 signaling can lead to complications in immune responses, especially during anti-PD-1-PD-L1 therapies.
Identifying the onset of patient deterioration is challenging despite the potential to respond to patients earlier with better vital sign monitoring and rapid response team (RRT) activation. In this study an ECG based software as a medical device, the Analytic for Hemodynamic Instability Predictive Index (AHI-PI), was compared to the vital signs of heart rate, blood pressure, and respiratory rate, evaluating how early it indicated risk before an RRT activation. A higher proportion of the events had risk indication by AHI-PI (92.
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- Scientists studied the kinematic Sunyaev-Zel'dovich (kSZ) effect using data from two telescopes, the South Pole Telescope and Herschel-SPIRE, covering a large area in the sky.
- They found a strong signal indicating that there is a trispectrum, which is a kind of pattern in the data, but it had contributions from other sources too, like cosmic microwave background lensing and foregrounds.
- By analyzing the data, they couldn't find just the kSZ signal alone, but they set limits on how long the reionization period lasted in the early universe, which helps us understand its history better.
Background: Learning health systems (LHSs) iteratively generate evidence that can be implemented into practice to improve care and produce generalizable knowledge. Pragmatic clinical trials fit well within LHSs as they combine real-world data and experiences with a degree of methodological rigor which supports generalizability.
Objectives: We established a pragmatic clinical trial unit ("RapidEval") to support the development of an LHS.