Efficacy and safety of curcumin in maintaining remission during disease-modifying antirheumatic drug withdrawal in rheumatoid arthritis at 52 weeks: a phase III double-blind, randomized placebo-controlled trial.

Curcumin has anti-inflammatory properties but current evidence is limited to advocate its use in rheumatoid arthritis (RA). We explored whether curcumin could maintain remission in patients with RA while tapering conventional synthetic Disease-Modifying Antirheumatic Drugs (csDMARD). In this patient-and investigator-blinded trial, adults with RA in sustained remission for more than six months were randomized to oral curcumin (1 g) with piperine (5 mg) twice daily or matching placebo.

Iron(iii)-catalyzed chelation assisted remote C-H bond oxygenation of 8-amidoquinolines.

Iron catalyzed site selective and chelation assisted C-H functionalization in 8-amidoquinolines is achieved. The remote C5-benzoxylation with benzoyl peroxide produced a variety of potentially bioactive 8-arylcarboxamido-5-benzoyloxy quinoline derivatives. The efficiency of the reaction reflects from the wide substrate scope with electronic differentiation on carboxamide and acyl peroxide in addition to tolerance of halo-substitutions on either of the aryls.

Response of heterogeneous vegetation to aerosol radiative forcing over a northeast Indian station.

Importance of atmospheric aerosols through direct and indirect effects on hydrological cycle is highlighted through multiple studies. This study tries to find how much the aerosols can affect evapo-transpiration (ET), a key component of the hydrological cycle over high NDVI (normalized difference vegetation index)/dense canopy, over Dibrugarh, known for vast tea plantation. The radiative effects of aerosols are calculated using satellite (Terra-MODIS) and reanalysis data on daily and monthly scales.

Copper-Catalyzed Direct Nitration on Aryl C-H Bonds by Concomitant Azidation-Oxidation with TMS Azide and TBHP under Aerobic Conditions.

An unprecedented copper-catalyzed in situ azidation-oxidation for the nitration of anilides and sulfonamides has been developed by direct C-H functionalization. This novel and efficient nitration protocol is achieved employing TMSN and TBHP without the exclusion of air or moisture. The synthetic applications of the 2-nitroanilides have been explored.

The role of computer imaging in facial plastic surgery consultation: a clinical study.

The influence of using computerized visual communication on preoperative communication between the surgeon and the patient was analysed. This was a retrospective study based on a questionnaire completed by 50 patients who had undergone various facial plastic surgical procedures. Prediction tracings and postoperative slides were compared by the surgeon.