Publications by authors named "B Vijitha Perera"
The vascular cell adhesion molecule-1 (VCAM-1) plays an important role in inflammation, where it facilitates the recruitment of leukocytes to the inflamed area via leukocytes' VLA-4 and endothelial cells' VCAM-1 interaction. VCAM-1 expression is also upregulated in certain cancers. VCAM-1 has seven Ig-like domains, with domains 1 and 4 shown to be critical for VLA-4 binding.
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- * It found that childhood challenging behaviors were significant predictors of later mental health outcomes, overshadowing the impacts of autism and ADHD when challenging behaviors were accounted for.
- * The research highlights the importance of early intervention strategies addressing challenging behaviors in children, particularly for those with co-occurring conditions like ADHD and autism, to improve adult mental health outcomes.
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- Lead (Pb) is identified as a neurotoxicant, with early exposure linked to long-term health issues, and this study investigates its impact on piwi-interacting RNAs (piRNAs), which are crucial for regulating gene expression through DNA methylation.
- The research evaluated the effects of perinatal Pb exposure on piRNA expression in the brains, livers, and reproductive tissues of adult mice, revealing that specific piRNAs were significantly downregulated in male brains exposed to Pb.
- Findings indicate that perinatal Pb exposure alters piRNA expression in a tissue- and sex-specific manner, possibly affecting gene regulation through DNA methylation processes.
Article Synopsis
- Maternal exposure to environmental chemicals like lead (Pb) and di(2-ethylhexyl) phthalate (DEHP) can lead to harmful health effects in offspring, potentially through epigenetic changes that may vary by tissue type and sex.
- The study analyzed DNA methylation changes in cerebral cortex, blood, and liver tissues of female mice exposed to Pb and DEHP during critical developmental periods.
- Results showed the cortex had the highest number of differentially methylated regions, indicating significant impacts on gene regulation, particularly affecting imprinted genes across different tissues and sexes due to chemical exposure.
Objective: To examine junior managers experiences of ethical leadership behaviors exhibited by their senior managers.
Methods: In this cross-sectional study, 263 junior health care managers working in public hospitals in Hail, Saudi Arabia were surveyed using a self-administered questionnaire between 20 November, 2022 and 15 February, 2023. Descriptive statistics and regression analysis were employed in the analysis.