The Simons Observatory: Design, Optimization, and Performance of Low-Frequency Detectors.

The Simons Observatory (SO) is a cosmic microwave background (CMB) experiment located in the Atacama Desert in Chile that will make precise temperature and polarization measurements over six spectral bands ranging from 27 to 285 GHz. Three small aperture telescopes (SATs) and one large aperture telescope (LAT) will house 60,000 detectors and cover angular scales between one arcminute and tens of degrees. We present the performance of the dichroic, low-frequency (LF) lenslet-coupled sinuous antenna transition-edge sensor (TES) bolometer arrays with bands centered at 27 and 39 GHz.

Norovirus replication, host interactions and vaccine advances.

Human noroviruses (HuNoVs) are the leading cause of acute gastroenteritis worldwide in all age groups and cause significant disease and economic burden globally. To date, no approved vaccines or antiviral therapies are available to treat or prevent HuNoV illness. Several candidate vaccines are in clinical trials, although potential barriers to successful development must be overcome.

Evaluation of the Drug-Drug Interaction Potential of Cannabidiol Against UGT2B7-Mediated Morphine Metabolism Using Physiologically Based Pharmacokinetic Modeling.

Morphine is a commonly prescribed opioid analgesic used to treat chronic pain. Morphine undergoes glucuronidation by UDP-glucuronosyltransferase (UGT) 2B7 to form morphine-3-glucuronide and morphine-6-glucuronide. Morphine is the gold standard for chronic pain management and has a narrow therapeutic index.

Importance of pesticide and additional food in pest-predator system: a theoretical study.

Integrated pest management (IPM) combines chemical and biological control to maintain pest populations below economic thresholds. The impact of providing additional food for predators on pest-predator dynamics, along- side pesticide use, in the IPM context remains unstudied. To address this issue, in this work a theoretical model was developed using differential equations, assuming Holling type II functional response for the predator, with additional food sources included.

RNA-dependent RNA polymerase of predominant human norovirus forms liquid-liquid phase condensates as viral replication factories.

Many viral proteins form biomolecular condensates via liquid-liquid phase separation (LLPS) to support viral replication and evade host antiviral responses, and thus, they are potential targets for designing antivirals. In the case of nonenveloped positive-sense RNA viruses, forming such condensates for viral replication is unclear and less understood. Human noroviruses (HuNoVs) are positive-sense RNA viruses that cause epidemic and sporadic gastroenteritis worldwide.