Publications by authors named "B Van Thielen"

Article Synopsis
  • Multisystem inflammatory syndrome in children (MIS-C) is a serious condition linked to COVID-19, causing inflammation and affecting multiple organs.
  • Research indicates that while antibodies are produced, there are issues with cell-mediated immune responses, particularly with natural killer (NK) cells, which show reduced functionality.
  • Possible treatments, like using CD16 cellular engagers, may improve NK cell function and help address the immune system's dysregulation associated with MIS-C.
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Influenza viruses pose a significant burden on global human health. Influenza has a broad cellular tropism in the airway, but how infection of different epithelial cell types impacts replication kinetics and burden in the airways is not fully understood. Using primary human airway cultures, which recapitulate the diverse epithelial cell landscape of the human airways, we investigated the impact of cell type composition on virus tropism and replication kinetics.

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Multisystem Inflammatory Syndrome in Children (MIS-C) is a severe complication of SARS-CoV-2 infection characterized by multi-organ involvement and inflammation. Testing of cellular function ex vivo to understand the aberrant immune response in MIS-C is limited. Despite strong antibody production in MIS-C, SARS-CoV-2 nucleic acid testing can remain positive for 4-6 weeks after infection.

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The performance of plasma metagenomic next-generation sequencing was evaluated in an immunocompromised pediatric population. The clinical impact was limited, with management changes in 13% of cases. Moreover, organisms thought to be non-pathogenic were commonly detected.

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