Publications by authors named "B Van Cranenbroek"
Aims/hypothesis: There is increasing evidence for heterogeneity in type 1 diabetes mellitus (T1D): not only the age of onset and disease progression rate differ, but also the risk of complications varies markedly. Consequently, the presence of different disease endotypes has been suggested. Impaired T and B cell responses have been established in newly diagnosed diabetes patients.
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- Immunological non-responders (INR) are HIV patients with persistently low CD4+ T-cell counts despite effective antiretroviral therapy, putting them at higher risk for health issues.
- A study comparing INR to immunological responders (IR) found that INR had older age, more severe HIV prior to treatment, and lower CD4+ T-cell counts, with an increase in activated and exhausted CD4+ T-cells.
- The research highlighted that INR demonstrated impaired lymphocyte cytokine production, while innate immune responses remained similar, suggesting a potential benefit of anti-PD1 therapy for this group.
Objectives: We explored the role of metabolic hormones and the B-cell repertoire in the association between nutritional status and vaccine responses.
Methods: In this prospective cohort study, nested within a larger randomized open-label trial, 211 South African children received two doses of measles vaccine and two or three doses of pneumococcal conjugate vaccine (PCV). Metabolic markers (leptin, ghrelin and adiponectin) and distribution of B-cell subsets (n = 106) were assessed at 18 months of age.
Immune responses are tightly regulated yet highly variable between individuals. To investigate human population variation of trained immunity, we immunized healthy individuals with Bacillus Calmette-Guérin (BCG). This live-attenuated vaccine induces not only an adaptive immune response against tuberculosis but also triggers innate immune activation and memory that are indicative of trained immunity.
View Article and Find Full Text PDFBackground: Endogenous steroid hormones have significant effects on inflammatory and immune processes, but the immunological activities of steroidogenesis precursors remain largely unexplored.
Methods: We conducted a systematic approach to examine the association between steroid hormones profile and immune traits in a cohort of 534 healthy volunteers. Serum concentrations of steroid hormones and their precursors (cortisol, progesterone, testosterone, androstenedione, 11-deoxycortisol and 17-OH progesterone) were determined by liquid chromatography-tandem mass spectrometry.