Radial artery pulse wave velocity: a new characterization technique and the instabilities associated with the respiratory phase and breath-holding.

. Pulse wave velocity (PWV) is a key diagnostic parameter of the cardiovascular system's state. However, approaches aimed at PWV characterization often suffer from inevitable drawbacks.

Infrared Thermography as a Powerful, Versatile, and Elegant Research Tool in Chemistry: Principles and Application to Catalysis and Adsorption.

In this Review, diverse chemical problems that have been approached by means of infrared thermography (IRT) are covered in depth. Moreover, some novel steps forward in this field are made, described and discussed. Namely, the latest-generation IRT performance capabilities are harnessed in full; the initial phase of catalytic CO oxidation (called "fast ignition") is presented at the 0.

A novel mutation in segregates with amyotrophic lateral sclerosis in a large family with early onset and fast progression.

To identify the genetic background of ALS segregating in a large Bedouin family in Israel. Exome sequencing was carried out on three siblings in a family segregating ALS, two affected and one without neurological symptoms. Filtering for causative variants and for modifiers was carried out.

Rare homozygosity in amyotrophic lateral sclerosis suggests the contribution of recessive variants to disease genetics.

Objective: to determine the occurrence of homozygous rare, in-silico damaging variants in a genetically relatively homogenous group of amyotrophic lateral sclerosis (ALS) patients.

Methods: Whole-exome-sequencing of 43 ALS patients of North-Africa Jewish origin was performed. Data were filtered to identify very rare homozygous recessive in-silico damaging variants, in genes annotated to ALS-associated cellular pathways.

Genomic alterations accompanying tumour evolution in colorectal cancer: tracking the differences between primary tumours and synchronous liver metastases by whole-exome sequencing.

Background: Colorectal cancer (CRC) patients with metastatic disease can become cured if neoadjuvant treatment can enable a resection. The search for predictive biomarkers is often performed on primary tumours tissue. In order to assess the effectiveness of tailored treatment in regard to the primary tumour the differences in the genomic profile needs to be clarified.