Advances in applications of the CRISPR/Cas9 system for respiratory diseases.

Genetic and environmental factors can have an impact on lung and respiratory disorders which are associated with severe symptoms and have high mortality rates. Many respiratory diseases are significantly influenced by genetic or epigenetic factors. Gene therapy offers a powerful approach providing therapeutic treatment for lung diseases.

Tofacitinib in Leprosy: A Novel Therapeutic Approach in Chronic Recalcitrant Type II Reactions.

Leprosy is a chronic, infectious, and debilitating disorder that primarily affects the skin and peripheral nerves. The disease course may be complicated by immune-mediated reactions during or after therapy, which may further worsen nerve damage. Type II lepra reaction (T2LR) is a painful inflammatory condition with systemic features, such as fever, tender erythematous nodules, arthritis, neuritis, orchitis, lymphadenitis, and iritis.

Force balance of opposing diffusive motors generates polarity-sorted microtubule patterns.

The internal organization of cells is largely determined by the architecture and orientation of the microtubule network. Microtubules serve as polar tracks for the selective transport of specific molecular motors toward either their plus or minus ends. How both motors reciprocally move microtubules and organize the network's arrangement and polarity is unknown.

Minimally Invasive Percutaneous Plate Osteosynthesis with Proximal Humerus Locking Plate for Pediatric Comminuted Subtrochanteric Femur Fracture: A Case Report.

Introduction: Pediatric subtrochanteric femoral fractures are uncommon, constituting only 4-10% of pediatric femoral fractures. These fractures present a significant challenge due to the strong muscular forces often resulting in malalignment, complicating treatment and reduction. This case is particularly noteworthy as it involves a comminuted subtrochanteric fracture, which is even rarer and demands advanced surgical intervention.

Comparative Analysis of Antimicrobial Properties and Physical Properties of Mineral Trioxide Aggregate Mixed With Distilled Water, Chlorhexidine, and Sodium Hypochlorite Solutions: An In Vitro Study.

Background:  Endodontics widely uses mineral trioxide aggregate (MTA) because of its excellent sealing ability, biocompatibility, and capacity to promote healing. However, the effectiveness of MTA can vary depending on the blending solution used. Endodontics commonly employ chlorhexidine (CHX) and sodium hypochlorite (NaOCl), but their impact on MTA's properties necessitates further investigation.