[Metazid-inducible vitamin B2 deficiency in rats and its prevention].

Rectal administration of metaside (20 mg per 100 g body weight) as suppositories for 10 days was found to cause vitamin B2 deficiency both in rats on low-vitamin B2 diet and in those on balanced diet. This appeared as decreased vitamin B2 levels in the liver and plasma. The design and application of suppositories containing the mixed preparation of metaside and riboflavin drug (in a dose of 100 micrograms per rat, which corresponds to the recommended daily requirement) completely prevents vitamin B2 deficiency.

[The use of preparations of methazid combined with riboflavin and pyridoxine for the correction of methazid-induced metabolic disorders of the B-group vitamins in rats].

It was established that 10-day administration of suppository methazide (20 mg per 100 g b. w.) induces B2 vitamin deficiency indicated by relevant hepatic and plasmic values.

[Effect of ethyl alcohol, nicotine, and both combined on certain parameters of chick embryo development].

Experiments on 220 chick embryos were made to study the embryotoxic action of ethyl alcohol and nicotine administered alone and combined, depending on the drug dose, route and frequency of administration. It has been disclosed that the toxic effect of the drugs manifests primarily at the cellular and subcellular levels and mainly affects the cardiovascular system and liver. The drug side effects increased on repeated administration.