Publications by authors named "B V S Sastry"
Article Synopsis
- * Echocardiography is crucial for diagnosing this condition, while other imaging techniques are becoming more important, and managing the disease requires a team of various medical specialists.
- * The seminar highlights best practices in treating infective endocarditis, covering aspects like its pathophysiology, pathogens, diagnosis, and prevention, while also discussing recent research and ongoing debates on treatment strategies.
Introduction: In SERAPHIN, a long-term, event-driven, double-blind randomised controlled trial in pulmonary arterial hypertension (PAH), macitentan 10 mg significantly reduced the risk of morbidity/mortality compared with placebo. Its open-label extension study (SERAPHIN OL) further assessed long-term safety and tolerability of macitentan 10 mg in PAH patients.
Methods: Patients in SERAPHIN who completed the double-blind treatment period or experienced a morbidity event during the study could enter SERAPHIN OL.
Article Synopsis
- - Pulmonary hypertension (PH) is common in India but faces significant care delivery challenges due to the country's lower middle-income status, with physicians noting inconsistent practices and a lack of dedicated programs for managing the condition.
- - Interviews with doctors revealed that frequent causes of PH included rheumatic mitral valve disease, coronary artery disease, and congenital heart disease, but diagnostic procedures and treatment protocols were often insufficient or varied.
- - Major barriers to effective PH management include limited physician training, absence of tailored treatment guidelines for lower middle-income countries, and socioeconomic factors affecting patient access to care and understanding of the disease.
G-protein coupled receptors and synaptic plasticity in sleep deprivation.
World J Psychiatry
November 2021
Insufficient sleep has been correlated to many physiological and psychoneurological disorders. Over the years, our understanding of the state of sleep has transcended from an inactive period of rest to a more active state involving important cellular and molecular processes. In addition, during sleep, electrophysiological changes also occur in pathways in specific regions of the mammalian central nervous system (CNS).
View Article and Find Full Text PDFBackground: The passive immunization of patients with SARS-CoV2 with convalescent plasma (CP) is theoretically beneficial in patients with end-stage renal disease who are immunosuppressed and unable to mount an adequate immune response. Hence, this study was conducted to evaluate the safety and efficacy of CP in patients with chronic kidney disease on hemodialysis with moderate-to-severe SARS-CoV2 infection.
Methods: A prospective observational cohort study was conducted in consecutive 68 moderate-to-severe SARS-CoV2 infected patients who were on maintenance hemodialysis or with acute worsening of chronic kidney disease which required initiation of hemodialysis.