Publications by authors named "B V P Perera"
Objective: The study aimed to examine the factor structure and psychometric properties of ethical leadership questionnaire (ELQ) by using a healthcare professional sample in Saudi Arabia.
Methods: A cross-sectional study was conducted, and a total of 387 healthcare professionals completed the 15-items ELQ questionnaire between 18 October, 2023 and 17 January, 2024. Exploratory factor analysis (EFA), confirmatory factor analysis (CFA), and a reliability test were performed on the obtained data.
Background: There is growing interest in understanding neurodevelopmental disorders such as Attention-deficit/hyperactivity disorder (ADHD) among doctors. However, the current understanding of ADHD and its association with mental well-being in doctors is limited.
Aims: This study investigated the significance of ADHD among doctors with mental health difficulties accessing a national mental health service for doctors in England.
The vascular cell adhesion molecule-1 (VCAM-1) plays an important role in inflammation, where it facilitates the recruitment of leukocytes to the inflamed area via leukocytes' VLA-4 and endothelial cells' VCAM-1 interaction. VCAM-1 expression is also upregulated in certain cancers. VCAM-1 has seven Ig-like domains, with domains 1 and 4 shown to be critical for VLA-4 binding.
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- * It found that childhood challenging behaviors were significant predictors of later mental health outcomes, overshadowing the impacts of autism and ADHD when challenging behaviors were accounted for.
- * The research highlights the importance of early intervention strategies addressing challenging behaviors in children, particularly for those with co-occurring conditions like ADHD and autism, to improve adult mental health outcomes.
Article Synopsis
- Lead (Pb) is identified as a neurotoxicant, with early exposure linked to long-term health issues, and this study investigates its impact on piwi-interacting RNAs (piRNAs), which are crucial for regulating gene expression through DNA methylation.
- The research evaluated the effects of perinatal Pb exposure on piRNA expression in the brains, livers, and reproductive tissues of adult mice, revealing that specific piRNAs were significantly downregulated in male brains exposed to Pb.
- Findings indicate that perinatal Pb exposure alters piRNA expression in a tissue- and sex-specific manner, possibly affecting gene regulation through DNA methylation processes.