Publications by authors named "B Uslu"
Investigation of the molecular interaction between apraclonidine, an α2-adrenergic receptor agonist, and bovine serum albumin using fluorescence and molecular docking techniques.
Spectrochim Acta A Mol Biomol Spectrosc
February 2025
Article Synopsis
- Apraclonidine (APR) is a selective drug used for diagnosing Horner's Syndrome, but it can affect human health negatively due to its accumulation from animal tissue.
- The study examined how APR interacts with the protein bovine serum albumin (BSA) using various techniques like fluorescence and molecular docking, finding that APR binds weakly to BSA.
- The thermodynamic analysis indicated that the binding is mainly driven by entropy changes and involves significant hydrophobic interactions, with APR showing higher binding affinity to Drug Site 2 compared to Drug Site 1.
Background: This study examined the effects of mothers' body mass index (BMI), emotional appetite, and food choices on children's growth curves and adiposity.
Methods: Data was collected from 492 mothers. The demographic characteristics and anthropometric measurements were obtained using a questionnaire.
Background: We aimed to examine the job satisfaction (JS), work stress (WS) and burnout (B) levels of healthcare workers (HCWs), who are at the forefront of the fight against the coronavirus (COVID-19) epidemic process, which negatively affects the whole world, by meta-analysis.
Methods: Articles, theses and papers in the literature before the COVID-19 (2014-2019) and during COVID-19 (2020-2022) were systematically reviewed. The sample size of 54 studies conducted from 13 countries was 49.
Through the utilization of fluorescence spectroscopy, electrochemical, and molecular docking methods, this research investigates the interaction between the antihistamine drug desloratadine and calf thymus double-stranded DNA (ct-dsDNA). Deoxyguanosine (dGuo) and deoxyadenosine (dAdo) oxidation signals were diminished by incubation with varying concentrations of desloratadine, as determined by differential pulse voltammetry (DPV). This change was ascribed to desloratadine's binding mechanism to ct-dsDNA.
View Article and Find Full Text PDFMulti-spectral and docking assessments to explore the combination of an antiviral drug, entecavir with bovine serum albumin.
Spectrochim Acta A Mol Biomol Spectrosc
December 2024
Article Synopsis
- The study investigated how entecavir (ETV) interacts with bovine serum albumin (BSA) using multispectral techniques and molecular docking.
- ETV binding to BSA resulted in significant fluorescence quenching, confirming a stable complex influenced by interactions like hydrophobic forces and hydrogen bonds.
- The analysis showed that ETV primarily binds to site I of BSA, with binding strength indicated by a moderate binding constant value of 1.47 × 10-4 to 0.×10 M.