Publications by authors named "B Umman"
Objective: Bicuspid aortic valve (BAV) is the most common congenital heart defect. Ascending aorta dilatation is related to BAV- and hypertension (HTN)-associated aortopathy. The aim of this study was to investigate aortic elasticity, as well as aortic deformation of the ascending aorta, using strain imaging, and to evaluate the possible relationship of biomarkers, such as endotrophin and matrix metalloproteinase-2 (MMP-2), with ascending aorta dilatation in patients with BAV- or HTN-associated aortopathy.
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- A study investigates how reperfusion following a heart attack affects the blood vessels in areas not directly damaged by the attack in patients undergoing primary percutaneous intervention (pPCI).
- Researchers monitored changes in blood flow and pressure in these non-injured vessels before and one hour after the procedure, finding significant decreases in blood flow velocity and increases in microvascular resistance after reperfusion.
- The findings suggest that injury to the microcirculation can spread to healthy heart regions, particularly when there is a larger area of infarction and greater microvascular damage in the affected vessel.
Article Synopsis
- Galectin-3 plays a significant role in COVID-19-related lung inflammation and fibrosis, but its impact on disease severity and prognosis is not well understood.
- A study with 68 hospitalized COVID-19 patients examined serum galectin-3 levels to predict severe outcomes like pneumonia severity, mortality, and ICU admission.
- Results showed that higher galectin-3 levels were linked to severe pneumonia, making it a potential biomarker for identifying patients at high risk for adverse clinical outcomes.
Prognostic value of the C-reactive protein-to-albumin ratio in patients with infective endocarditis.
Eur Rev Med Pharmacol Sci
December 2022
Article Synopsis
- Infective endocarditis (IE) is a serious condition that can lead to complications and death, and the study explores the C-reactive protein-to-albumin ratio (CAR) as a potential indicator of patient outcomes.
- The research analyzed data from 196 IE patients over five years, dividing them into those with serious health outcomes (64 patients) and those without (132 patients), and measured their CAR levels upon hospital admission.
- The findings indicated that higher CAR values were linked to worse prognoses, with a specific cutoff point predicting adverse outcomes, making CAR a promising tool for assessing IE patient risk.
Background Intramyocardial edema and hemorrhage are key pathological mechanisms in the development of reperfusion-related microvascular damage in ST-segment-elevation myocardial infarction. These processes may be facilitated by abrupt restoration of intracoronary pressure and flow triggered by primary percutaneous coronary intervention. We investigated whether pressure-controlled reperfusion via gradual reopening of the infarct-related artery may limit microvascular injury in patients undergoing primary percutaneous coronary intervention.
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