Publications by authors named "B Ulmer"
Human induced pluripotent stem cells (hiPSCs) are an invaluable tool to study molecular mechanisms on a human background. Culturing stem cells at an oxygen level different from their microenvironmental niche impacts their viability. To understand this mechanistically, dermal skin fibroblasts of 52 probands were reprogrammed into hiPSCs, followed by either hyperoxic (20 % O) or physioxic (5 % O) culture and proteomic profiling.
View Article and Find Full Text PDFAim: The real-world benefits of continuous glucose monitoring (CGM) in the broad type 2 diabetes (T2D) population are not well studied. Our study evaluated the impact of CGM use on health care resource utilization over 12 months in adults with T2D.
Materials And Methods: This retrospective cohort analysis used Optum's de-identified Market Clarity data of >79 million people to evaluate CGM use in people with T2D who were treated with non-insulin (NIT), basal insulin (BIT) and prandial insulin therapy (PIT).
Macroautophagy (hereafter autophagy) is a lysosomal degradation pathway that functions in nutrient recycling and as a mechanism of innate immunity. Previously, we reported a novel host-bacteria interaction between cariogenic and bitter taste receptor (T2R14) in gingival epithelial cells (GECs), leading to an innate immune response. Further, might be using the host immune system to inhibit other Gram-positive bacteria, such as .
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- Primary carnitine deficiency (PCD) is a genetic disorder caused by mutations in the SLC22A5 gene, leading to muscle weakness and heart issues due to impaired carnitine transport.
- Researchers created two types of stem cell lines to better understand how OCTN2 mutations affect heart muscle cells, finding that these cells generated less force and had altered metabolic processes compared to control cells.
- The study identified ferroptosis, a specific cell death pathway, as a new mechanism potentially contributing to heart problems in PCD, highlighting the importance of OCTN2 in cardiac health.
Publications describe the relevance of the AT-rich interactive domain-containing protein 1A () mutation in gastric adenocarcinoma, which occurs predominantly in the microsatellite instable (MSI)- and Epstein-Barr virus (EBV)-associated subtypes. It is unclear whether potential therapeutic, prognostic or morphologic descriptions are not epiphenomena of MSI (or EBV). Since personalised therapeutics are largely lacking for oesophageal adenocarcinoma (EAC), clinical trials investigating the efficacy of these therapeutics specifically in this subgroup are useful.
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