Publications by authors named "B Ujhelyi"
Stimulation of Piezo1 mechanosensitive channels inhibits adipogenesis in thyroid eye disease.
J Clin Endocrinol Metab
January 2025
Context: Increased orbital tissue volume due to matrix expansion, orbital fibroblast (OF) proliferation and adipocyte differentiation are the hallmarks of thyroid eye disease (TED). Their combination with the presence of hyaluronan-bound excess water in the constrains of the bony orbit results in increased intraorbital pressure. High intraorbital pressure, along with changes in the mechanical properties of orbital tissues, may lead to the activation of mechanosensitive receptors.
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- The study investigates how myofibroblast differentiation (MD) affects hyaluronan (HA) turnover in orbital fibroblasts, particularly in the context of thyroid eye disease (TED).
- Using primary cultures from TED and non-TED tissue samples, researchers induced MD and measured various factors like proliferation, HA levels, and enzyme expressions related to HA metabolism.
- Findings revealed that MD leads to lower HA turnover by inhibiting certain enzymes while increasing HA synthesis, suggesting that targeting specific hyaluronidases could be a new approach to treat TED.
Orbital connective tissue changes are contributors to the pathogenesis in thyroid eye disease (TED). Activated fibroblasts respond to immune stimuli with proliferation and increased hyaluronan (HA) production. Cyclosporin A (CsA) was reported to be beneficial in the treatment of TED.
View Article and Find Full Text PDFOrbital connective tissue expansion is a hallmark of Graves’ orbitopathy (GO). In moderate-to-severe active GO, glucocorticoids (GC) are the first line of treatment. Here we show that hydrocortisone (HC), prednisolone (P), methylprednisolone (MP), and dexamethasone (DEX) inhibit the hyaluronan (HA) production of orbital (OF) and dermal (DF) fibroblasts.
View Article and Find Full Text PDFIntroduction: Dysthyroid optic neuropathy (DON) is a rare, severe form of thyroid eye disease, in which decreased visual acuity is accompanied by characteristic MRI findings. The treatment of DON has always been a challenge.
Case Presentation: In a patient in whom visual acuity deteriorated on the left eye, mannitol 20% 200 mL followed by furosemide 40 mg 6 h later, administered daily, were initiated on the day of admission.