Publications by authors named "B Trzaskowski"
Article Synopsis
- The flexibility of 2,2'-bipyridyl-based diamine and coordination domain denticity allowed for the creation of four different structures stabilized by silver-silver pairs.
- Reactions with 2,6-diformylpyridine produced silver(I)-stabilized molecular tweezer, trefoil knot, and Solomon link.
- The 1,8-naphthyridine-based dialdehyde led to the formation of [2]catenanes and trefoil knot, with notable close distances between silver ions and two assemblies exhibiting interesting luminescent properties.
Article Synopsis
- Crownphyrinogens and crownphyrins are macrocycles that blend features from both porphyrinoids and crown ethers, allowing for unique reactivity due to their dual-nature cavity.
- When Ni(II) and Pd(II) are inserted into these structures, they form coordination compounds that can result in either monomeric or accordion-like dimeric assemblies, depending on the oxidation state.
- Reactions with Na(I) and K(I) predominantly involve the crown ether segment, leading to notable dimeric complexes, and larger crownphyrins can create binuclear complexes that demonstrate distinct reactivity properties from each of its cavities.
The synthesis of [2]rotaxanes stoppered with one or two dipyrromethane groups has opened a route for the construction of mechanically interlocked molecules incorporating various porphyrinoid stations. The exploitation of those precursors allowed the creation of [3]rotaxanes and [2]catenanes based on the calix[4]phyrin motif, presenting intriguing molecular dynamics. The intrinsic flexibility of the porphyrinoid allowed the introduction of a new type of molecular motion within the rotaxanes, termed fluttering.
View Article and Find Full Text PDFNew amide conjugates 1-6 of hydroxycinnamic acids (HCA) and 5'-deoxy-5-fluorocytidine (5-dFCR), the prodrug of 5-fluorouracil (5-FU), were synthesized and tested against pancreatic cancer lines (PDAC). The compounds showed slightly higher efficacy against primary BxPC-3 cells (IC values of 14-45 μM) than against metastatic AsPC-1 (IC values of 37-133 μM), and similar to that of 5-FU for both PDAC lines. Compound 1, which has a -(acetyloxy)coumaroyl substituent, was found to be the most potent (IC = 14 μM) with a selectivity index of approximately 7 to normal dermal fibroblasts (IC = 96 μM).
View Article and Find Full Text PDFRecently, pyrrole cages have been synthesized that encapsulate ion pairs and silver(I) clusters to form intricate supramolecular capsules. We report here a computational analysis of these structures using density functional theory combined with a semiempirical tight-binding approach. We find that for neutral pyrrole cages, the Gibbs free energies of formation provide reliable predictions for the ratio of bound ions.
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