Publications by authors named "B Toye"
Article Synopsis
- The study focused on the effectiveness of percutaneous synovial biopsy (PSB) and joint aspiration in diagnosing prosthetic infections in patients undergoing revision shoulder arthroplasty, comparing their results to those from open culture biopsies.
- Conducted across four medical centers with 69 patients, the research found that 19% tested positive for infection with PSB, while 23% tested positive through open biopsy, showing that PSB had lower sensitivity but fairly good specificity.
- Results indicated that while PSB is somewhat reliable, its diagnostic accuracy is limited, highlighted by a 37% sensitivity rate and 81% specificity, and the study also explored how the biopsy location within the shoulder might relate to infection
Direct molecular detection of amoxicillin-susceptible in urine samples from children with suspected urinary tract infection: A potential tool to improve antibiotic stewardship and patient care.
J Assoc Med Microbiol Infect Dis Can
October 2019
Background: Rapid detection of amoxicillin-susceptible (ASEC) urinary tract infections (UTIs) could have a significant impact on patient care and improve antibiotic stewardship. This is especially true for infants and children, for whom antibiotic choices are more limited than for adults.
Methods: A real-time polymerase chain reaction (PCR) uniplex panel for detection of ASEC using PCR assays for and five resistance genes ( , , , , and ) and an internal control was designed.
Background: Antimicrobial stewardship interventions to curtail the use of third-generation cephalosporins and antipseudomonal penicillins for the treatment of complicated appendicitis in children are challenging given the tendency to treat complicated disease with broad-spectrum antimicrobials. Reasons for this are unclear, but there is a paucity of contemporary microbiologic data associated with the child presenting with either acute perforated or gangrenous appendicitis. This study aimed to justify the appropriateness of an empiric regimen consisting of ampicillin, tobramycin/gentamicin plus metronidazole and to analyze duration of postoperative therapy.
View Article and Find Full Text PDFIncidental post-partum isolation of in an asymptomatic woman.
J Assoc Med Microbiol Infect Dis Can
March 2019
A 25-year-old Somali-born female was admitted to the hospital in active labour. Following post-partum hemorrhage, grew from a blood culture and the placenta. Identification and relatedness were determined through reverse transcriptase polymerase chain reaction (RT-PCR), single nucleotide polymorphism (SNP), and whole genome sequencing.
View Article and Find Full Text PDFObjective: Molecular methods to detect diarrheal pathogens are increasingly being used in place of conventional methods. We compared a new multiplex real-time PCR assay for detection of both bacterial and viral gastroenteritis agents, the Allplex™ Gastrointestinal Panel Assays (AGPA), to conventional methods (stool culture for bacterial pathogens and electron microscopy (EM) for viral pathogens).
Results: Gastrointestinal viruses, in particular norovirus genogroup II viruses, were detected by the AGPA in a high number of specimens that were negative by EM.