Publications by authors named "B Tomlinson"
Background: Elevated low-density lipoprotein (LDL) cholesterol is a major risk factor for cardiovascular disease. Statins are the cornerstone of preventing and treating cardiovascular disease and can reduce LDL cholesterol by more than 60%. Although statins have high tolerability and safety, as the number of users increases, their adverse reactions in the liver, kidneys, skeletal muscles, and their potential to induce diabetes have also received widespread attention.
View Article and Find Full Text PDFAn up-to-date review of emerging biologic therapies for hypercholesterolemia.
Expert Opin Biol Ther
January 2025
Introduction: Hypercholesterolemia and other lipid disorders are major causes of atherosclerotic cardiovascular disease (ASCVD). Statins have been the mainstay of lipid-lowering therapy for many years, but they may not be adequate to achieve the target low-density lipoprotein (LDL) cholesterol levels and there are other residual lipid risk factors.
Areas Covered: This article reviews the biologic therapies in development for hypercholesterolemia identified by a PubMed search.
Aim: Mental wellbeing has been one of the most prominent health concerns in Aotearoa New Zealand and has only been exacerbated by the COVID-19 pandemic. Here we explored factors associated with anxiety and happiness in a mid-pandemic climate in Aotearoa.
Methods: Analyses were performed on the anxiety and happiness scores from the wellbeing survey in December 2020 (Statistics NZ Tatauranga Aotearoa; 30,000 responders contacted for the Household Labour Force Survey).
Article Synopsis
- * 61 participants consumed either the hawthorn drink or placebo over 8 weeks, and metrics like blood pressure, lipid profiles, and glucose levels were recorded, noting no significant differences between the two groups.
- * Results suggested a minimal trend towards fewer adverse effects with hawthorn, but overall findings did not indicate significant benefits, prompting a recommendation for longer studies with controlled calorie intake.
Article Synopsis
- The rise of large language models (LLMs) has sparked debates over their environmental impacts, with some studies suggesting they have a high carbon footprint, while others claim they can promote sustainability.
- A comparative analysis shows that LLMs can have a lower environmental impact than human labor, especially in the U.S., with certain LLMs being significantly more efficient in terms of energy, carbon emissions, and costs.
- Despite the potential benefits of using LLMs over human workers, economic and practical considerations likely mean a combination of both in the workforce, and further research is needed to assess the long-term sustainability of increasingly larger LLMs.