Publications by authors named "B Takase"
Background: Phase I clinical trial of an artificial oxygen carrier (liposome-encapsulated hemoglobin vesicles [HbVs]) is safely completed, considering the other clinical application. Herein, we aimed to investigate the resuscitation effects of HbVs in cases of lethal hemorrhage, including the mechanisms involved.
Methods: Optical mapping analysis (OMP) and electrophysiological studies (EPS), immunostaining pathological examination for hypoxia-inducible factor-1α (HIF1-alpha) in the heart tissue, and blood troponin I (TnI) level measurements were performed in rats that underwent five rounds of spontaneous arterial bleeding with up to 65% hemorrhage.
Article Synopsis
- - The study aimed to understand how serum small dense low-density lipoprotein cholesterol (sdLDL-C) and triglyceride (TG) levels relate to cardiovascular events in patients with coronary artery disease (CAD) and type 2 diabetes who are on statins.
- - Participants were categorized into four groups based on their sdLDL-C and TG levels, with cardiovascular events tracked over a median of 1419 days, resulting in 34 events during the study.
- - Results indicated that patients with sdLDL-C levels of 40.0 mg/dL or higher faced a greater risk of cardiovascular events, even when their TG levels were below 150 mg/dL, highlighting the residual risk present despite statin treatment.