Publications by authors named "B Tack"
Invasive non-typhoidal Salmonella (iNTS) disease is an under-recognized high-burden disease causing major health and socioeconomic issues in sub-Saharan Africa (sSA), predominantly among immune-naïve infants and young children, including those with recognized comorbidities such as HIV infection. iNTS disease is primarily caused by Salmonella enterica serovar Typhimurium sequence type (ST) 313 and 'African-restricted clades' of Salmonella Enteritidis ST11 that have emerged across the African continent as a series of epidemics associated with acquisition of new antimicrobial resistance. Due to genotypes with a high prevalence of antimicrobial resistance and scarcity of therapeutic options, these NTS serovars are designated by the World Health Organization as a priority pathogen for research and development of interventions, including vaccines, to address and reduce NTS associated bacteremia and meningitis in sSA.
View Article and Find Full Text PDFBackground: Invasive non-typhoidal (iNTS) disease is a significant health concern in sub-Saharan Africa. While our knowledge of a larger-scale variation is growing, understanding of the subnational variation in iNTS disease occurrence is lacking, yet crucial for targeted intervention.
Method: We performed a systematic review of reported occurrences of iNTS disease in sub-Saharan Africa, consulting literature from PubMed, Embase and Web of Science published since 2000.
Article Synopsis
- Severe bacterial infections in children require quick and effective antibiotic treatment, but challenges were identified in a study at a Kisantu hospital on non-typhi Salmonella bloodstream infections.
- While 98.4% of children received antibiotics, there were significant issues with timing, administration, and dosing accuracy, with only 78.3% receiving antibiotics on the day of admission.
- Problems included the use of inappropriate administration practices, poor-quality oral formulations, and a lack of essential dosing instructions, highlighting an urgent need for improvements in antibiotic management for pediatric care.
Antimicrobial resistant Salmonella enterica serovar Concord (S. Concord) is known to cause severe gastrointestinal and bloodstream infections in patients from Ethiopia and Ethiopian adoptees, and occasional records exist of S. Concord linked to other countries.
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