Publications by authors named "B T Ngadjui"
Epidemiological evidence associates latent infection with the development of neuropsychiatric disorders, and various immunological and environmental factors play key pathophysiological roles through host immune response alterations. We investigated the cognitive and motor alterations occurring in the terminal stage of infection in rats, and whether a low-protein diet, a high-fat diet or ovariectomy may accelerate their development, given the role of malnutrition and menopause on immunity and resistance to infection. In two sets of experiments, 2-month-old (157.
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- Cerebral toxoplasmosis is becoming more common in immunocompetent people due to mutant strains that are resistant to current treatments, posing a significant health risk.
- An experimental study was conducted on rats, where severe toxoplasmosis was induced and then treated with various fractions from a medicinal plant known for its potential health benefits.
- The results showed that the ethyl acetate fraction specifically helped improve cognitive impairments and other neurological deficits caused by toxoplasmosis, indicating its potential as a therapeutic option.
A previously undescribed bislabdane diterpenoid namely aframomumlabdane (), was isolated from the seed of together with seven known compounds (-). Their structures were established based on a comprehensive analysis of HR-ESI-MS, in conjunction with their 1D and 2D-NMR data. Compound was evaluated for its cytotoxic activity against four cancer cell lines: A549, HepG2, SPC212 and DLD-1.
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- * A proposed biogenetic pathway suggests these compounds originate from coniferyl alcohol, indicating a systematic approach to understanding their formation.
- * Antimicrobial testing showed one compound had moderate antibacterial activity, while others demonstrated good to very good antiplasmodial and antitrypanosomal effects against resistant strains of various pathogens.
Canthium Lam. is a genus of flowering plants of the Rubiaceae family with about 80-102 species mainly distributed in Asia, tropical and subtropical Africa. The genus is closely related to Keetia E.
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