Publications by authors named "B T Livingston"
Transcription factors are frequent cancer driver genes, exhibiting noted specificity based on the precise cell of origin. We demonstrate that ZIC1 exhibits loss-of-function (LOF) somatic events in group 4 (G4) medulloblastoma through recurrent point mutations, subchromosomal deletions and mono-allelic epigenetic repression (60% of G4 medulloblastoma). In contrast, highly similar SHH medulloblastoma exhibits distinct and diametrically opposed gain-of-function mutations and copy number gains (20% of SHH medulloblastoma).
View Article and Find Full Text PDFThe ongoing outbreak of highly pathogenic avian influenza (HPAI) H5N1 of the clade 2.3.4.
View Article and Find Full Text PDFArticle Synopsis
- A recent outbreak of H5 avian influenza in cattle has spread across the U.S., affecting not only birds but also other mammals, including humans, with mostly mild symptoms reported in infected individuals.
- Research shows that mice with immunity to previous influenza strains were protected against severe H5N1 infections, and similarly, mice vaccinated with a live-attenuated influenza vaccine exhibited good protection against lethal H5N1 challenges.
- Ferrets with mixed immunity from vaccination or previous infections were also protected against a variant of the H5N1 virus, suggesting that factors beyond just antibody response, like T cell memory, might play a crucial role in providing protection against this virus.
Due to their frequent coexistence in many polymicrobial infections, including in patients with cystic fibrosis or burn/chronic wounds, many studies have investigated the mechanistic details of the interaction between the opportunistic pathogens and rapidly outcompetes under cocultivation conditions which is mediated by several of 's virulence factors. Here, we report that polyphosphate (polyP), an efficient stress defense system and virulence factor in , plays a role in the pathogen's ability to inhibit and kill in a contact-independent manner. We show that cells characterized by low polyP levels are less detrimental to growth and survival while the Gram-positive pathogen is significantly more compromised by the presence of cells that produce high levels of polyP.
View Article and Find Full Text PDFImportance: Substance use is high among American Indian/Alaska Native adolescents. Pain interference is a risk factor for substance use, and identifying potential protective factors, such as Tribal identity, is important to help inform culturally grounded substance use prevention strategies.
Objective: To examine the protective potential of Tribal identity as a moderator in the association between pain interference and substance use in American Indian/Alaska Native adolescents.