Publications by authors named "B Szili"
Objective: The mainstay therapy of hypothyroidism is levothyroxine (LT4). In most cases lifelong treatment is warranted, therefore, choosing adequate doses are of paramount significance. The purpose of this study was to assess several factors that have been proposed to influence LT4 therapy including etiology of hypothyroidism, gender, age, bodyweight, BMI, concomitant drug use, disease severity and time since diagnosis in patients with stable, adequately controlled hypothyroidism.
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- Cyclic thrombocytopenia (CTP) is a rare blood disorder where patients experience fluctuating platelet counts, and its underlying causes are not well understood.
- In a recent study, a 41-year-old woman with a 22-year history of CTP underwent extensive tests including bone marrow biopsy and genetic analysis to explore possible physiological defects associated with the disease.
- The results revealed normal blood cell production with some abnormal platelet characteristics, a genetic variant linked to a different blood disorder, and no autoimmune activity, adding valuable information to the limited understanding of CTP.
Genetic alterations are well known to be related to the pathogenesis and prognosis of papillary thyroid carcinoma (PTC). Some miRNA expression dysregulations have previously been described in the context of cancer development including thyroid carcinoma. In our study, we performed original molecular diagnostics on tissue samples related to our own patients.
View Article and Find Full Text PDFRapidly restoring vitamin D levels to normal might be desirable in certain clinical situations. Larger doses of supplementation, have been shown to increase bone loss and the risk of falls. The optimal way to perform vitamin D loading safely and effectively is still not well elucidated.
View Article and Find Full Text PDFContext: Increasing diagnostic sensitivity in the detection of thyroid cancer has led to uncertainties in the optimal surgical approach of the smaller, low risk tumors. Current ATA guidelines consider lobectomy safe between 1 and 4 cm, while ETA advocates for primary total thyroidectomy to avoid reoperation, as final risk stratification is based on the histological results.
Objective: Our aim was to compare the differences in outcomes that are potentially achievable with adherence to the different guidelines, and also to examine the predictive value of clinical parameters on the incidence of postoperative risk factors.