Cocaine and seizure protection in mice of varying brain weights.

The effects of cocaine administration on seizure duration and proportion of animals that seized were examined in mice genetically selected for differential brain weight. In the two experiments reported, mice of the Fuller brain weight lines and of the Binghamton Heterogeneous stock were used. In Experiment 1, 21 day old male and female mice were administered either 0, 5, 10 or 20 mg/kg of cocaine hydrochloride.