Publications by authors named "B Sykes"

Gastrin is an important hormone involved in gastric acid secretion. Despite its importance, validated methods other than radioimmunoassay (RIA) to assess serum gastrin concentrations in horses are lacking. This study aims to determine the agreement between ELISA and RIA in quantifying equine serum gastrin concentrations.

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Viscoelastic monitoring of horse coagulation is increasing due to its advantages over traditional coagulation testing. The use of a point-of-care viscoelastic coagulation monitor (VCM Vet™) has been validated for use in horses using native whole blood (NWB) but has not been assessed using citrated whole blood (CWB), a technique that might have advantages in practicality and precision. Blood was collected from 70 horses, tested in duplicate immediately using NWB (T0), and stored at room temperature as CWB for testing in duplicate at 1 (T1) and 4 (T4) hours after venipuncture for comparison to NWB.

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Background: Prioritising equine welfare, making evidenced-based policy, and consistent decision-making across sports are crucial to maintaining the social licence for equestrian sport. Regulations on the use of omeprazole during competition differ; all regulators argue that their rules prioritise welfare. This discrepancy is a matter of concern to the public and equestrian stakeholders.

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Article Synopsis
  • Islet transplantation is a promising alternative to whole pancreas transplantation for type 1 diabetes patients facing severe hypoglycemia, but challenges remain regarding cost-effectiveness and donor sensitization.
  • This pilot study utilized advanced nuclear magnetic resonance spectroscopy to examine human pancreatic tissue before and after cold-storage, revealing signs of hypoxia and subsequent recovery of islet viability post-incubation.
  • A correlation was found between specific metabolic changes in the pancreatic tissue and the responsiveness of the isolated islets, indicating that assessing these features could help identify suitable pancreases and enhance transplantation outcomes.
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Horses are exquisitely sensitive to tetanus neurotoxin and are exposed to the risk of infection with throughout life. The vaccine against tetanus is highly effective at preventing disease, whereas tetanus in unvaccinated populations is associated with high mortality rates. Current guidelines in New Zealand and Australia for the available vaccine contain contradictions and limitations surrounding the optimal tetanus immunisation protocols for both adult horses and foals.

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