Publications by authors named "B Swenson"
Article Synopsis
- The study examined the relationship between omega-3 PUFAs and stroke risk across 29 global cohorts, focusing on total, ischemic, and hemorrhagic strokes.
- Results showed that higher levels of eicosapentaenoic acid reduced the incidence of total and ischemic strokes by 17% and 18%, respectively, while docosahexaenoic acid also lowered these risks by 12% and 14%.
- The findings indicate that although higher omega-3 PUFA levels are linked to reduced total and ischemic stroke risks, there is no effect on hemorrhagic strokes.
Thyroid hormones play a key role in differentiation and metabolism and are known regulators of gene expression through both genomic and epigenetic processes including DNA methylation. The aim of this study was to examine associations between thyroid hormones and DNA methylation. We carried out a fixed-effect meta-analysis of epigenome-wide association study (EWAS) of blood DNA methylation sites from 8 cohorts from the ThyroidOmics Consortium, incorporating up to 7073 participants of both European and African ancestry, implementing a discovery and replication stage.
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- Fibrinogen is crucial for blood clotting and inflammation, and its circulating levels may be influenced by differences in DNA methylation at specific CpG sites.
- An epigenome-wide association study analyzed blood DNA methylation and fibrinogen levels in over 18,000 diverse participants, revealing significant associations through advanced statistical models.
- The study identified a total of 83 replicated CpG sites linked to fibrinogen, highlighting genes involved in inflammation, with many associations being affected but still significant after adjusting for C-reactive protein (CRP) levels.
Article Synopsis
- * A large study investigated blood-based DNA methylation patterns in relation to kidney function and found 69 DNA sites linked to estimated glomerular filtration rate and 7 to urinary albumin-to-creatinine ratio, pointing to potential genetic markers for CKD.
- * Further validation in kidney tissue highlighted specific genes associated with kidney function and suggested that certain DNA methylation changes could have causal effects, implicating pathways in blood cell migration and immune response related to kidney health.
Article Synopsis
- * The study identified 100 significant CpG sites that account for 11.6% of serum urate variance, particularly noting five CpGs associated with SLC2A9, a major gene influencing serum urate levels.
- * Additionally, some of these CpGs also appear to mediate effects of genetic variants related to serum urate and are linked to metabolic syndrome, suggesting a potential blood DNA methylation signature for assessing cardiometabolic risk factors.