Publications by authors named "B Svanberg"
Article Synopsis
- - The research highlights the unclear impacts of cognitive load on driving behavior and the need for better methods to measure it for traffic safety studies, advocating for more comprehensive driver monitoring systems.
- - Current approaches often oversimplify cognitive load as a single factor, ignoring its complex nature that involves various mental responses influenced by specific driving tasks and environments.
- - A driving simulator study utilized multiple physiological measures (like heart rate and EEG) to analyze cognitive load during a testing task, suggesting that examining a range of responses can enhance the understanding and measurement of cognitive load in driving contexts.
Here we describe for the first time the distinctive pharmacological profile for (3)-3-(2,3-difluorophenyl)-3-methoxypyrrolidine (IRL752), a new phenyl-pyrrolidine derivative with regioselective central nervous system transmission-enhancing properties. IRL752 (3.7-150 µmol/kg, s.
View Article and Find Full Text PDFIRL790 ([2-(3-fluoro-5-methanesulfonylphenoxy)ethyl](propyl)amine, mesdopetam) is a novel compound in development for the clinical management of motor and psychiatric disabilities in Parkinson disease. The discovery of IRL790 was made applying a systems pharmacology approach based on in vivo response profiling. The chemical design idea was to develop a new type of DA D3/D2 receptor type antagonist built on agonist rather than antagonist structural motifs.
View Article and Find Full Text PDFWe measured physiological variables on nine car drivers to capture moderate magnitudes of mental load (ML) during driving in prolonged and repeated city and highway field conditions. Ecological validity was optimized by avoiding any artificial interference to manipulate drivers ML, drivers were alone in the car, they were free to choose their paths to the target, and the repeated drives familiarized drivers to the procedure. Our aim was to investigate if driver's physiological variables can be reliably measured and used as predictors of moderate individual levels of ML in naturally occurring unpredictably changing field conditions.
View Article and Find Full Text PDFThe dopaminergic stabilizers pridopidine and ordopidine enhance cortico-striatal Arc gene expression.
J Neural Transm (Vienna)
November 2014
Article Synopsis
- Pridopidine and ordopidine are dopaminergic stabilizers that reduce hyperactivity caused by psychostimulants and promote behavior when activity is low, distinguishing their effects from other D2 receptor antagonists.
- Both compounds were shown to significantly increase the expression of the immediate early gene Arc in both the frontal cortex and striatum, suggesting a unique mechanism of synaptic activation compared to standard D1 and D2 compounds.
- The increase in Arc expression in the striatum also indicated a link between dopamine D2 receptor antagonism and enhanced synaptic activity, underscoring the unique neuropharmacological profile of these stabilizers.