Publications by authors named "B Staude"
Article Synopsis
- Population-based studies show conflicting data on preterm birth rates during the COVID-19 pandemic, highlighting a need for better understanding of birth characteristics.
- This study compared perinatal care and very preterm birth rates before and during different phases of the COVID-19 pandemic in Hesse, Germany, using data from a quality assurance registry.
- Findings indicated that very preterm birth rates decreased during the pandemic, especially during the second lockdown, with fewer births among mothers with serious health issues contributing to this decline.
Article Synopsis
- Microbiome dysbiosis can lead to health issues, with bronchopulmonary dysplasia (BPD) being linked to both prenatal and postnatal factors, especially intra-amniotic infections.
- This study compared bacterial signatures in amniotic fluid from intact pregnancies and preterm deliveries to unravel their connection to varying severities of BPD.
- Results showed that preterm delivery amniotic fluid had increased 16S rRNA genes with altered bacterial composition, highlighting specific bacterial communities associated with different BPD severity levels.
Even more than 50 years after its initial description, bronchopulmonary dysplasia (BPD) remains one of the most important and lifelong sequelae following premature birth. Tremendous efforts have been undertaken since then to reduce this ever-increasing disease burden but a therapeutic breakthrough preventing BPD is still not in sight. The inflammatory response provoked in the immature lung is a key driver of distorted lung development and impacts the formation of alveolar, mesenchymal, and vascular structures during a particularly vulnerable time-period.
View Article and Find Full Text PDFBronchopulmonary dysplasia (BPD) remains one of the most devastating consequences of preterm birth resulting in life-long restrictions in lung function. Distorted lung development is caused by its inflammatory response which is mainly provoked by mechanical ventilation, oxygen toxicity and bacterial infections. Dysfunction of resident lung mesenchymal stem cells (MSC) represents one key hallmark that drives BPD pathology.
View Article and Find Full Text PDFPreterm birth poses a global challenge with a continuously increasing disease burden during the last decades. Advances in understanding the etiopathogenesis did not lead to a reduction of prematurely born infants so far. A balanced development of the host microbiome in early life is key for the maturation of the immune system and many other physiological functions.
View Article and Find Full Text PDF