Introducing community-based mental health support in Serbia: A qualitative study on experiences and needs of long-term psychiatric users.

Background: Mental health (MH) system in Serbia still relies heavily on the medical model with very restricted availability of community-based support. The aim of this study was to provide insight into the everyday experiences and unmet needs of psychiatric users suffering from schizophrenia spectrum disorders in Serbia who are also users of community MH services.

Method: We recruited the participants ( = 11; 9 males; aged 26-65,  = 48.

The long non-coding RNA GAS5 contributes to the suppression of inflammatory responses by inhibiting NF-κB activity.

Introduction: Nuclear factor kappa B (NF-κB) is a key regulator of immune and inflammatory responses. Glucocorticoid drugs (GC) act through the glucocorticoid receptor (GR) as immunosuppressant also in pediatric patients inhibiting NF-κB activity. The long non-coding RNA GAS5 interacts with the GR, influencing GC activity.

A novel procedure for selection of molecular descriptors: QSAR model for mutagenicity of nitroaromatic compounds.

Nitroaromatic compounds (NACs) stand out as pervasive organic pollutants, prompting an imperative need to investigate their hazardous effects. Computational chemistry methods play a crucial role in this exploration, offering a safer and more time-efficient approach, mandated by various legislations. In this study, our focus lay on the development of transparent, interpretable, reproducible, and publicly available methodologies aimed at deriving quantitative structure-activity relationship models and testing them by modelling the mutagenicity of NACs against the Salmonella typhimurium TA100 strain.

Psychological Distress Is Associated With Inflammatory Bowel Disease Manifestation and Mucosal Inflammation.

Background: Stress is a potentially significant risk factor for the occurrence and progression of inflammatory bowel disease (IBD).

Methods: The study analyzed the level of stress, anxiety, and depression in patients with Crohn's disease (CD; n = 50) and ulcerative colitis (UC; n = 54) in comparison with non-IBD controls (n = 100), using Perceived Stress Scale (PSS), Patient Health Questionnaire (PHQ-9), and Hospital Anxiety and Depression Scale (HADS) questionnaires. Additionally, a correlation between psychological scores and expression of IL17A, IL17F, and IL23A genes in the intestinal mucosa of IBD patients was assessed.

Reduction of CO in the presence of light excited-state hydride transfer reaction in a NADPH-inspired derivative.

The photo-catalytic reduction of CO into chemical feedstocks using solar energy has attracted vast interest in environmental science because of global warming. Based on our previous study on the CO complex with one of the benzimidazoline (BI) derivatives, we explore the photochemical reduction of CO in one of the benzimidazoline derivatives (1,3-dimethyl-5,6-diol-2,3-dihydro-1-benzimidazole) by quantum-chemical methods. Our results reveal that carbon dioxide can be reduced to formate (HCOO) by a hydride transfer reaction in the excited state of this complex of benzimidazoline derivative and CO.