["Signs for the whole rest of the life". The house as symbol and autobiographical substrate in letters, dreams and literary texts by by Anna Freud].

The house as object and symbol preoccupied Anna Freud from childhood onwards. This article traces these ideas in letters, autobiographical documents and literary texts. It focuses on the phantasmal construction of a dream house; on the organisation, loss and later efforts to recover Hochrotherd; on casual birthday poems dedicated to Anna, praising the country house, as well as on the purchase of a weekend cottage in Walberswick reflected in dreams related to the process of inner detachment from the dead father.

Beta-adrenergic modulation of currents produced by rat cardiac Na+ channels expressed in Xenopus laevis oocytes.

In Xenopus oocytes coexpressing beta 2-adrenergic receptors and the rat cardiac alpha SkM2 Na+ channel, superfusion with 10 microM isoproterenol led to modest (approximately 30%) increases in peak Na+ inward current. Intracellular injection of cAMP and of protein kinase A (PKA) catalytic subunit reproduced this increase, showing that the second messenger pathway involves PKA dependent phosphorylation. Coexpression of the Na+ channel beta 1 subunit had no influence on the modulation.